TGGE Maxi System

Please note: These instruments are discontinued.
Accessories are yet available. Please see section "Accessories".

  • Long separation distance for analysis of complex samples
  • High parallel sample throughput
  • High reproducibility thanks to Peltier powered temperature gradient

The heart of the Biometra TGGE Maxi system is a temperature block powered by Peltier technology. Due to microprocessor control a strictly linear gradient can be generated providing maximum reproducibility. Thus assay conditions can be much better (and easier) controlled compared to conventional chemical gradients or temporal gradients using water baths.

Cost saving
TGGE provides fast and cost effective mutation screening of PCR fragments. Following pre-screening with TGGE only those samples are selected for direct sequencing that are different from the wildtype (standard). Thus the total number of sequenced samples can be dramatically reduced, saving time and money.

In contrast to direct sequencing TGGE can also detect mutations in mixed DNA samples. Whenever heterozygous DNA is to be analyzed, direct sequencing will not give a clear signal for the position of the mutation. This is especially problematic when the mutated material is masked by a high background of normal cells. TGGE reliably detects mutations in a 1:10 dilution (and higher) of wildtype DNA.